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සැකිල්ල:Infobox drug/testcases9

බැඳියන් එක්කරන්න
විකිපීඩියා වෙතින්


vaccine_type

[සංස්කරණය]
Side by side comparison
{{Infobox drug}}{{Infobox drug/sandbox}}
Adenovirus vaccine
Bottles of the vaccine
Vaccine description
TargetAdenovirus
එන්නත් වර්ගයFoo
Clinical data
AHFS/Drugs.comMonograph
License data
ලබාදෙන
මාර්ගය		By mouth
හැඳිනුම්
UNII
Adenovirus vaccine
Bottles of the vaccine
Vaccine description
TargetAdenovirus
Vaccine typeFoo
Clinical data
AHFS/Drugs.comMonograph
License data
Routes of
administration		By mouth
Identifiers
UNII

PubChem PID, SID

[සංස්කරණය]

විරේචනය 'PID |PubChem=3007

Side by side comparison
{{Infobox drug}}{{Infobox drug/sandbox}}
Amfetamine
Clinical data
වෙළඳ නාමAdderall, Dyanavel XR, Evekeo, others
වෙනත් නාමα-methylphenethylamine
AHFS/Drugs.comamphetamine
ලබාදෙන
මාර්ගය		Medical: oral (ingestion), nasal inhalation, intravenous
Recreational: oral, nasal inhalation, insufflation, rectal, intravenous
ATC කේතය
Pharmacokinetic data
BioavailabilityOral 75–100%
ප්‍රෝටීන බන්ධනය15–40%
බහිස්‍රාවයPrimarily renal;
pH-dependent range: 1–75%
හැඳිනුම්
  • (RS)-1-phenylpropan-2-amine
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
NIAID ChemDB
PDB ligand
Chemical and physical data
සූත්‍රයC9H13N
මවුලික ස්කන්ධය135.21 g·mol−1
Amfetamine
Clinical data
Trade namesAdderall, Dyanavel XR, Evekeo, others
Other namesα-methylphenethylamine
AHFS/Drugs.comamphetamine
Routes of
administration		Medical: oral (ingestion), nasal inhalation, intravenous
Recreational: oral, nasal inhalation, insufflation, rectal, intravenous
ATC code
Pharmacokinetic data
BioavailabilityOral 75–100%
Protein binding15–40%
ExcretionPrimarily renal;
pH-dependent range: 1–75%
Identifiers
  • (RS)-1-phenylpropan-2-amine
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
NIAID ChemDB
PDB ligand
Chemical and physical data
FormulaC9H13N
Molar mass135.21 g·mol−1

විරේචනය 'SID |PubChem=7003 (?)

Side by side comparison
{{Infobox drug}}{{Infobox drug/sandbox}}
Amfetamine
Clinical data
වෙළඳ නාමAdderall, Dyanavel XR, Evekeo, others
වෙනත් නාමα-methylphenethylamine
AHFS/Drugs.comamphetamine
ලබාදෙන
මාර්ගය		Medical: oral (ingestion), nasal inhalation, intravenous
Recreational: oral, nasal inhalation, insufflation, rectal, intravenous
ATC කේතය
Pharmacokinetic data
BioavailabilityOral 75–100%
ප්‍රෝටීන බන්ධනය15–40%
බහිස්‍රාවයPrimarily renal;
pH-dependent range: 1–75%
හැඳිනුම්
  • (RS)-1-phenylpropan-2-amine
CAS Number
PubChem SID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
NIAID ChemDB
PDB ligand
Chemical and physical data
සූත්‍රයC9H13N
මවුලික ස්කන්ධය135.21 g·mol−1
Amfetamine
Clinical data
Trade namesAdderall, Dyanavel XR, Evekeo, others
Other namesα-methylphenethylamine
AHFS/Drugs.comamphetamine
Routes of
administration		Medical: oral (ingestion), nasal inhalation, intravenous
Recreational: oral, nasal inhalation, insufflation, rectal, intravenous
ATC code
Pharmacokinetic data
BioavailabilityOral 75–100%
Protein binding15–40%
ExcretionPrimarily renal;
pH-dependent range: 1–75%
Identifiers
  • (RS)-1-phenylpropan-2-amine
CAS Number
PubChem SID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
NIAID ChemDB
PDB ligand
Chemical and physical data
FormulaC9H13N
Molar mass135.21 g·mol−1

Amphetamine

[සංස්කරණය]

විරේචනය FA

Side by side comparison
{{Infobox drug}}{{Infobox drug/sandbox}}
Amfetamine
An image of the amphetamine compound
A 3d image of the D-amphetamine compound
Clinical data
උච්චාරණයඅසන්නi/æmˈfɛtəmiːn/
වෙළඳ නාමAdderall, Dyanavel XR, Evekeo, others
වෙනත් නාමα-methylphenethylamine
AHFS/Drugs.comamphetamine
License data
Dependence
liability		Physical: none
Psychological: moderate
Addiction
liability		Moderate
ලබාදෙන
මාර්ගය		Medical: oral (ingestion), nasal inhalation, intravenous
Recreational: oral, nasal inhalation, insufflation, rectal, intravenous
ATC කේතය
Legal status
Legal status
Pharmacokinetic data
BioavailabilityOral 75–100%
ප්‍රෝටීන බන්ධනය15–40%
පරිවෘත්තියAmphetamine only:
CYP2D6, DBH, FMO3
පරිවෘත්තීය ද්‍රව්‍ය4-hydroxyamphetamine, 4-hydroxynorephedrine, 4-hydroxyphenylacetone, benzoic acid, hippuric acid, norephedrine, phenylacetone
ක්‍රියාවේ ආරම්භයIR dosing: 30–60 minutes[1]
XR dosing: 1.5–2 hours[2][3]
ඉවත්වීමේ අර්ධ-ආයුකාලයD-amph:9–11 hours
L-amph:11–14 hours
pH-dependent: 8–31 hours
ක්‍රියා කාලසීමාවIR dosing: 3–7 hours[4]
XR dosing: 12 hours
බහිස්‍රාවයPrimarily renal;
pH-dependent range: 1–75%
හැඳිනුම්
  • (RS)-1-phenylpropan-2-amine
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
NIAID ChemDB
PDB ligand
Chemical and physical data
සූත්‍රයC9H13N
මවුලික ස්කන්ධය135.20622 g/mol
ත්‍රිමාණ සැකැස්ම (JSmol)
Chirality1:1 mixture (racemate)
ඝනත්වය0.9±0.1 g/cm3
ද්‍රවාංකය11.3 °C (52.3 °F) (predicted)[5]
තාපාංකය203 °C (397 °F) at 760 mmHg
  • NC(CC1=CC=CC=C1)C
  • InChI=1S/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3
  • Key:KWTSXDURSIMDCE-UHFFFAOYSA-N
Amfetamine
An image of the amphetamine compound
A 3d image of the D-amphetamine compound
Clinical data
Pronunciationඅසන්නi/æmˈfɛtəmiːn/
Trade namesAdderall, Dyanavel XR, Evekeo, others
Other namesα-methylphenethylamine
AHFS/Drugs.comamphetamine
License data
Dependence
liability		Physical: none
Psychological: moderate
Addiction
liability		Moderate
Routes of
administration		Medical: oral (ingestion), nasal inhalation, intravenous
Recreational: oral, nasal inhalation, insufflation, rectal, intravenous
ATC code
Legal status
Legal status
Pharmacokinetic data
BioavailabilityOral 75–100%
Protein binding15–40%
MetabolismAmphetamine only:
CYP2D6, DBH, FMO3
Metabolites4-hydroxyamphetamine, 4-hydroxynorephedrine, 4-hydroxyphenylacetone, benzoic acid, hippuric acid, norephedrine, phenylacetone
Onset of actionIR dosing: 30–60 minutes[1]
XR dosing: 1.5–2 hours[2][3]
Elimination half-lifeD-amph:9–11 hours
L-amph:11–14 hours
pH-dependent: 8–31 hours
Duration of actionIR dosing: 3–7 hours[4]
XR dosing: 12 hours
ExcretionPrimarily renal;
pH-dependent range: 1–75%
Identifiers
  • (RS)-1-phenylpropan-2-amine
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
NIAID ChemDB
PDB ligand
Chemical and physical data
FormulaC9H13N
Molar mass135.20622 g/mol
3D model (JSmol)
Chirality1:1 mixture (racemate)
Density0.9±0.1 g/cm3
Melting point11.3 °C (52.3 °F) (predicted)[5]
Boiling point203 °C (397 °F) at 760 mmHg
  • NC(CC1=CC=CC=C1)C
  • InChI=1S/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3
  • Key:KWTSXDURSIMDCE-UHFFFAOYSA-N

Aspirin

[සංස්කරණය]

විරේචනය

Side by side comparison
{{Infobox drug}}{{Infobox drug/sandbox}}
Aspirin
Clinical data
උච්චාරණයacetylsalicylic acid /əˌsiːtəlˌsælᵻˈsɪlᵻk/
වෙනත් නාම2-acetoxybenzoic acid
acetylsalicylate
acetylsalicylic acid
O-acetylsalicylic acid
AHFS/Drugs.comMonograph
MedlinePlusa682878
License data
ගර්භනී
කාණ්ඩය
  • AU: C
ලබාදෙන
මාර්ගය		Most commonly oral, also rectal, lysine acetylsalicylate may be given intravenously or intramuscularly
ATC කේතය
Legal status
Legal status
  • AU: S2 (Pharmacy medicine) except when given intravenously (in which case it is schedule 4), used in animal medicine (schedule 5/6) or when the dose is higher than usual.
  • UK: General sales list (GSL, OTC)
  • US: OTC
Pharmacokinetic data
Bioavailability80–100%[6]
ප්‍රෝටීන බන්ධනය80–90%[7]
පරිවෘත්තියHepatic, (CYP2C19 and possibly CYP3A), some is also hydrolysed to salicylate in the gut wall.[7]
ඉවත්වීමේ අර්ධ-ආයුකාලයDose-dependent; 2–3 hours for low doses, 15–30 hours for large doses.[7]
බහිස්‍රාවයUrine (80–100%), sweat, saliva, feces[6]
හැඳිනුම්
  • 2-(acetoxy)benzoic acid
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
Chemical and physical data
සූත්‍රයC9H8O4
මවුලික ස්කන්ධය180.157 g/mol
ත්‍රිමාණ සැකැස්ම (JSmol)
ඝනත්වය1.40 g/cm3
ද්‍රවාංකය135 °C (275 °F)
තාපාංකය140 °C (284 °F) (decomposes)
ජලයේ ද්‍රාව්‍යතාව3 mg/mL (20 °C)
  • O=C(Oc1ccccc1C(=O)O)C
  • InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
  • Key:BSYNRYMUTXBXSQ-UHFFFAOYSA-N
Aspirin
Clinical data
Pronunciationacetylsalicylic acid /əˌsiːtəlˌsælᵻˈsɪlᵻk/
Other names2-acetoxybenzoic acid
acetylsalicylate
acetylsalicylic acid
O-acetylsalicylic acid
AHFS/Drugs.comMonograph
MedlinePlusa682878
License data
Pregnancy
category
  • AU: C
Routes of
administration		Most commonly oral, also rectal, lysine acetylsalicylate may be given intravenously or intramuscularly
ATC code
Legal status
Legal status
  • AU: S2 (Pharmacy medicine) except when given intravenously (in which case it is schedule 4), used in animal medicine (schedule 5/6) or when the dose is higher than usual.
  • UK: General sales list (GSL, OTC)
  • US: OTC
Pharmacokinetic data
Bioavailability80–100%[6]
Protein binding80–90%[7]
MetabolismHepatic, (CYP2C19 and possibly CYP3A), some is also hydrolysed to salicylate in the gut wall.[7]
Elimination half-lifeDose-dependent; 2–3 hours for low doses, 15–30 hours for large doses.[7]
ExcretionUrine (80–100%), sweat, saliva, feces[6]
Identifiers
  • 2-(acetoxy)benzoic acid
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
Chemical and physical data
FormulaC9H8O4
Molar mass180.157 g/mol
3D model (JSmol)
Density1.40 g/cm3
Melting point135 °C (275 °F)
Boiling point140 °C (284 °F) (decomposes)
Solubility in water3 mg/mL (20 °C)
  • O=C(Oc1ccccc1C(=O)O)C
  • InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
  • Key:BSYNRYMUTXBXSQ-UHFFFAOYSA-N

Methamphetamine

[සංස්කරණය]
Side by side comparison
{{Infobox drug}}{{Infobox drug/sandbox}}
Infobox drug/testcases9
An image of the methamphetamine compound
Ball-and-stick model of the methamphetamine molecule
Clinical data
උච්චාරණය/ˌmɛθæmˈfɛtəmiːn/
වෙළඳ නාමDesoxyn
වෙනත් නාමN-methylamphetamine, N,α-dimethylphenethylamine, desoxyephedrine
AHFS/Drugs.comMonograph
License data
Dependence
liability		Physical: none
Psychological: high
Addiction
liability		Very high
ලබාදෙන
මාර්ගය		Medical: oral (ingestion), intravenous[8]
Recreational: oral, intravenous, intramuscular, subcutaneous, smoke inhalation, insufflation, rectal, vaginal
ATC කේතය
Legal status
Legal status
Pharmacokinetic data
BioavailabilityOral: 70%[9]
IV: 100%[9]
ප්‍රෝටීන බන්ධනයVaries widely[10]
පරිවෘත්තියCYP2D6,[11] DBH,[12] FMO3,[13] XM-ligase,[14] and ACGNAT[15]
ක්‍රියාවේ ආරම්භයRapid[16]
ඉවත්වීමේ අර්ධ-ආයුකාලය5–30 hours[17]
ක්‍රියා කාලසීමාව10–20 hours[16]
බහිස්‍රාවයPrimarily renal
හැඳිනුම්
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
Chemical and physical data
සූත්‍රයC10H15N
මවුලික ස්කන්ධය149.24 g·mol−1
ත්‍රිමාණ සැකැස්ම (JSmol)
Chirality1:1 mixture (racemate)
ද්‍රවාංකය3 °C (37 °F) (predicted)[5]
තාපාංකය212 °C (414 °F) at 760 mmHg[18]
  • N(C(Cc1ccccc1)C)C
  • InChI=1S/C10H15N/c1-9(11-2)8-10-6-4-3-5-7-10/h3-7,9,11H,8H2,1-2H3 YesY
  • Key:MYWUZJCMWCOHBA-UHFFFAOYSA-N YesY
Infobox drug/testcases9
An image of the methamphetamine compound
Ball-and-stick model of the methamphetamine molecule
Clinical data
Pronunciation/ˌmɛθæmˈfɛtəmiːn/
Trade namesDesoxyn
Other namesN-methylamphetamine, N,α-dimethylphenethylamine, desoxyephedrine
AHFS/Drugs.comMonograph
License data
Dependence
liability		Physical: none
Psychological: high
Addiction
liability		Very high
Routes of
administration		Medical: oral (ingestion), intravenous[8]
Recreational: oral, intravenous, intramuscular, subcutaneous, smoke inhalation, insufflation, rectal, vaginal
ATC code
Legal status
Legal status
Pharmacokinetic data
BioavailabilityOral: 70%[9]
IV: 100%[9]
Protein bindingVaries widely[10]
MetabolismCYP2D6,[11] DBH,[12] FMO3,[13] XM-ligase,[14] and ACGNAT[15]
Onset of actionRapid[16]
Elimination half-life5–30 hours[17]
Duration of action10–20 hours[16]
ExcretionPrimarily renal
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
Chemical and physical data
FormulaC10H15N
Molar mass149.24 g·mol−1
3D model (JSmol)
Chirality1:1 mixture (racemate)
Melting point3 °C (37 °F) (predicted)[5]
Boiling point212 °C (414 °F) at 760 mmHg[18]
  • N(C(Cc1ccccc1)C)C
  • InChI=1S/C10H15N/c1-9(11-2)8-10-6-4-3-5-7-10/h3-7,9,11H,8H2,1-2H3 YesY
  • Key:MYWUZJCMWCOHBA-UHFFFAOYSA-N YesY

Order of sections

[සංස්කරණය]

Container only

[සංස්කරණය]
Side by side comparison
{{Infobox drug}}{{Infobox drug/sandbox}}
Niacin
හැඳිනුම්
  • abc
CAS Number
Niacin
Identifiers
  • abc
CAS Number

Refs

[සංස්කරණය]
  1. 1 2 "amphetamine/dextroamphetamine". amphetamine/dextroamphetamine. WebMD. "Onset of action: 30–60 min".
  2. 1 2 Millichap JG (2010). "Chapter 9: Medications for ADHD". In Millichap JG (ed.). Attention Deficit Hyperactivity Disorder Handbook: A Physician's Guide to ADHD (2nd ed.). New York, USA: Springer. p. 112. ISBN 9781441913968.
    Table 9.2 Dextroamphetamine formulations of stimulant medication
    Dexedrine [Peak:2–3 h] [Duration:5–6 h] ...
    Adderall [Peak:2–3 h] [Duration:5–7 h]
    Dexedrine spansules [Peak:7–8 h] [Duration:12 h] ...
    Adderall XR [Peak:7–8 h] [Duration:12 h]
    Vyvanse [Peak:3–4 h] [Duration:12 h]
  3. 1 2 Brams M, Mao AR, Doyle RL (September 2008). "Onset of efficacy of long-acting psychostimulants in pediatric attention-deficit/hyperactivity disorder". Postgrad. Med. 120 (3): 69–88. doi:10.3810/pgm.2008.09.1909. PMID 18824827.
  4. 1 2 Mignot EJ (October 2012). "A practical guide to the therapy of narcolepsy and hypersomnia syndromes". Neurotherapeutics. 9 (4): 739–752. doi:10.1007/s13311-012-0150-9. PMC 3480574. PMID 23065655.
  5. 1 2 3 4 "Amphetamine". Amphetamine.
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