Diazepam

විකිපීඩියා, නිදහස් විශ්වකෝෂය වෙතින්
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Diazepam
Diazepam structure.svg
Diazepam ball-and-stick model.png
Systematic (IUPAC) name
7-Chloro-1,3-dihydro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one[1]
Clinical data
Trade names Valium, Vazepam, others[1]
AHFS/Drugs.com Monograph
MedlinePlus a682047
Licence data US FDA:link
Pregnancy cat. C (AU) D (US)
Legal status Prescription Only (S4) (AU) Schedule IV (CA) P.O.M otherwise Class C (UK) Schedule IV (US) Psychotropic schedule IV (UN) Prescription only
Dependence liability Moderate
Routes By mouth, IM, IV, rectal
Pharmacokinetic data
Bioavailability 76% (64–97%) by mouth, 81% (62–98%) rectal[2]
Metabolism LiverCYP2B6 (minor route) to desmethyldiazepam, CYP2C19 (major route) to inactive metabolites, CYP3A4 (major route) to desmethyldiazepam
Half-life (50 hours); 20–100 hours (36–200 hours for main active metabolite desmethyldiazepam)
Excretion Kidney
Identifiers
CAS number 439-14-5 YesY[??]
ATC code N05BA01
PubChem CID 3016
IUPHAR ligand 3364
DrugBank DB00829
ChemSpider 2908 YesY
UNII Q3JTX2Q7TU YesY
KEGG D00293 YesY
ChEBI CHEBI:49575 YesY
ChEMBL CHEMBL12 YesY
Chemical data
Formula C16H13ClN2O 
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Diazepam (ඩයසිපෑම්) යනු බෙන්සොඩයසපීන (benzodiazepine) පවුලට අයත් ඖෂධයකි.[3] [4]

මූලාශ්‍ර[සංස්කරණය]

  1. 1.0 1.1 "National Highway Traffic Safety Administration Drugs and Human Performance Fact Sheet- Diazepam". Archived from the original on 2017-03-27. සම්ප්‍රවේශය 2017-11-13. 
  2. Dhillon, S; Oxley, J; Richens, A (1 March 1982). "Bioavailability of diazepam after intravenous, oral and rectal administration in adult epileptic patients.". British Journal of Clinical Pharmacology. 13 (3): 427–432. ISSN 0306-5251. PMC 1402110Freely accessible. PMID 7059446. doi:10.1111/j.1365-2125.1982.tb01397.x. 
  3. "විෂ නසන දේත් විෂ වෙයිද?". දිවයින. සම්ප්‍රවේශය 2018-08-29. 
  4. "දරුවන්ට උණවලිප්පුව ඇතිවන හැටි". දිවයින. සම්ප්‍රවේශය 2018-08-29. 
"https://si.wikipedia.org/w/index.php?title=Diazepam&oldid=433360" වෙතින් සම්ප්‍රවේශනය කෙරිණි