වේසොප්‍රෙසින්

arginine vasopressin
Identifiers
Aliases	vasopressin-neurophysin 2-copeptinADHcopeptinargipressinvasopressin-neurophysin II-copeptinprepro-arginine-vasopressin-neurophysin IIAVP-NPIIAVPvasopressinarginine-vasopressinantidiuretic hormoneneurohypophysealprepro-AVP-NP II
External IDs	GeneCards: [1]
RNA expression pattern
	More reference expression data
Orthologs
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	Wikidata
View/Edit Human

Systematic (IUPAC) name
	1-{[(4R,7S,10S,13S,16S,19R)-19-Amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-p rolyl-L-arginylglycinamide
Clinical data
Legal status	?
Pharmacokinetic data
Protein binding	1%
Metabolism	ප්‍රධාන වශයෙන් අක්මාව සහ වෘක්කවල
Half-life	10–20 මිනිත්තු
Excretion	මූත්‍ර
Identifiers
CAS number	11000-17-2 [??]
ATC code	H01BA01
PubChem	CID 644077
IUPHAR ligand	2168
DrugBank	DB00067
ChemSpider	559126
UNII	Y4907O6MFD
KEGG	D00101
ChEBI	CHEBI:9937
ChEMBL	CHEMBL373742
Synonyms	Antidiuretic hormone (ADH); arginine vasopressin (AVP); argipressin
Chemical data
Formula	C46H65N15O12S2
	InChI InChI=1S/C46H65N15O12S2 /c47-27-22-74-75-23-33(45(73)61-17-5-9-34(61)44(72)56-28(8-4-16-53-46(51)52)39(67)54-21-37(50)65)60-43(71)32(20-36(49)64)59-40(68)29(14-15-35(48)63)55-41(69)31(18-24-6-2-1-3-7-24)58-42(70)30(57-38(27)66)19-25-10-12-26(62)13-11-25/h1-3,6-7,10-13,27-34,62H,4-5,8-9,14-23,47H2,(H2,48,63)(H2,49,64)(H2,50,65)(H,54,67)(H,55,69)(H,56,72)(H,57,66)(H,58,70)(H,59,68)(H,60,71)(H4,51,52,53)/t27-,28-,29-,30-,31-,32-,33-,34-/m0/s1 ; Key:KBZOIRJILGZLEJ-LGYYRGKSSA-N ;
Physical data
Density	1.6±0.1 g/cm³

වේසොප්‍රෙසින්, හෙවත් ප්‍රතිමෞත්‍රල්‍ය හෝර්මෝනය (ADH), ආර්ජිනීන් වේසොප්‍රෙසින් (AVP) හෝ ආර්ජිප්‍රෙසින්,^[1] යනුවෙන් හැඳින්වෙන්නේ හෝර්මෝන synthesized as a peptide prohormone in neurons in the hypothalamus, and is converted to AVP. It then travels down the axon of that cell, which terminates in the posterior pituitary, and is released from vesicles into the circulation in response to extracellular fluid hypertonicity (hyperosmolality). AVP has two primary functions. First, it increases the amount of solute-free water reabsorbed back into the circulation from the filtrate in the kidney tubules of the nephrons. Second, AVP constricts arterioles, which increases peripheral vascular resistance and raises arterial blood pressure.^[2]^[3]^[4]

A third function is possible. Some AVP may be released directly into the brain from the hypothalamus, and may play an important role in social behavior, sexual motivation and pair bonding, and maternal responses to stress.^[5]

Vasopressin induces differentiation of stem cells into cardiomyocytes and promotes heart muscle homeostasis.^[6]

It has a very short half-life, between 16–24 minutes.^[4]

ආශ්‍රේයයන්[සංස්කරණය]

↑ Anderson DA (2012). Dorland's Illustrated Medical Dictionary (32nd ed.). Elsevier. ISBN 978-1-4160-6257-8.
↑ Marieb, Elaine (2014). Anatomy & physiology. Glenview, IL: Pearson Education, Inc. ISBN 978-0-321-86158-0. {{cite book}}: Unknown parameter |name-list-format= ignored (help)
↑ Caldwell HK, Young WS III (2006). "Oxytocin and Vasopressin: Genetics and Behavioral Implications". In Lajtha A, Lim R (eds.). Handbook of Neurochemistry and Molecular Neurobiology: Neuroactive Proteins and Peptides (3rd ed.). Berlin: Springer. pp. 573–607. ISBN 978-0-387-30348-2. {{cite book}}: Unknown parameter |chapterurl= ignored (help)
↑ ^4.0 ^4.1 Babar SM (October 2013). "SIADH associated with ciprofloxacin". The Annals of Pharmacotherapy. 47 (10): 1359–63. doi:10.1177/1060028013502457. PMID 24259701.
↑ Insel TR (March 2010). "The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior". Neuron (English බසින්). 65 (6): 768–79. doi:10.1016/j.neuron.2010.03.005. PMC 2847497. PMID 20346754.{{cite journal}}: CS1 maint: unrecognized language (link)
↑ Costa A, Rossi E, Scicchitano BM, Coletti D, Moresi V, Adamo S (September 2014). "Neurohypophyseal Hormones: Novel Actors of Striated Muscle Development and Homeostasis". review. European Journal of Translational Myology. 24 (3): 3790. doi:10.4081/bam.2014.3.217. PMC 4756744. PMID 26913138.

වැඩිදුර කියවීමට[සංස්කරණය]

Rector, Floyd C.; Brenner, Barry M. (2004). Brenner & Rector's the kidney (7th ed.). Philadelphia: Saunders. ISBN 978-0-7216-0164-9. {{cite book}}: Unknown parameter |name-list-format= ignored (help)

සැකිල්ල:PDB Gallery සැකිල්ල:Hormones සැකිල්ල:Renal physiology සැකිල්ල:Neuropeptides සැකිල්ල:Neurotransmitters සැකිල්ල:Oxytocin and vasopressin receptor modulators

[Dorlands-1] Anderson DA (2012). Dorland's Illustrated Medical Dictionary (32nd ed.). Elsevier. ISBN 978-1-4160-6257-8.

[Marieb-2] Marieb, Elaine (2014). Anatomy & physiology. Glenview, IL: Pearson Education, Inc. ISBN 978-0-321-86158-0. {{cite book}}: Unknown parameter |name-list-format= ignored (help)

[isbn0-387-30348-0-3] Caldwell HK, Young WS III (2006). "Oxytocin and Vasopressin: Genetics and Behavioral Implications". In Lajtha A, Lim R (eds.). Handbook of Neurochemistry and Molecular Neurobiology: Neuroactive Proteins and Peptides (3rd ed.). Berlin: Springer. pp. 573–607. ISBN 978-0-387-30348-2. {{cite book}}: Unknown parameter |chapterurl= ignored (help)

[babar2013-4] 4.0 ^4.1 Babar SM (October 2013). "SIADH associated with ciprofloxacin". The Annals of Pharmacotherapy. 47 (10): 1359–63. doi:10.1177/1060028013502457. PMID 24259701.

[5] Insel TR (March 2010). "The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior". Neuron (English බසින්). 65 (6): 768–79. doi:10.1016/j.neuron.2010.03.005. PMC 2847497. PMID 20346754.{{cite journal}}: CS1 maint: unrecognized language (link)

[Costa_2014-6] Costa A, Rossi E, Scicchitano BM, Coletti D, Moresi V, Adamo S (September 2014). "Neurohypophyseal Hormones: Novel Actors of Striated Muscle Development and Homeostasis". review. European Journal of Translational Myology. 24 (3): 3790. doi:10.4081/bam.2014.3.217. PMC 4756744. PMID 26913138.

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