Systematic (IUPAC ) name
1-{[(4R,7S,10S,13S,16S,19R)-19-Amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-p rolyl-L-arginylglycinamide
Clinical data
Legal status
?
Pharmacokinetic data
Protein binding
1%
Metabolism
ප්රධාන වශයෙන් අක්මාව සහ වෘක්ක වල
Half-life
10–20 මිනිත්තු
Excretion
මූත්ර
Identifiers
CAS number
11000-17-2 Y [?? ]
ATC code
H01 BA01
PubChem
CID 644077
IUPHAR ligand
2168
DrugBank
DB00067
ChemSpider
559126 Y
UNII
Y4907O6MFD Y
KEGG
D00101 Y
ChEBI
CHEBI:9937 Y
ChEMBL
CHEMBL373742 Y
Synonyms
Antidiuretic hormone (ADH); arginine vasopressin (AVP); argipressin
Chemical data
Formula
C 46 H 65 N 15 O 12 S 2
InChI=1S/C46H65N15O12S2
/c47-27-22-74-75-23-33(45(73)61-17-5-9-34(61)44(72)56-28(8-4-16-53-46(51)52)39(67)54-21-37(50)65)60-43(71)32(20-36(49)64)59-40(68)29(14-15-35(48)63)55-41(69)31(18-24-6-2-1-3-7-24)58-42(70)30(57-38(27)66)19-25-10-12-26(62)13-11-25/h1-3,6-7,10-13,27-34,62H,4-5,8-9,14-23,47H2,(H2,48,63)(H2,49,64)(H2,50,65)(H,54,67)(H,55,69)(H,56,72)(H,57,66)(H,58,70)(H,59,68)(H,60,71)(H4,51,52,53)/t27-,28-,29-,30-,31-,32-,33-,34-/m0/s1 Y Key:KBZOIRJILGZLEJ-LGYYRGKSSA-N Y
Physical data
Density
1.6±0.1 g/cm³
arginine vasopressin Identifiers Aliases vasopressin-neurophysin 2-copeptinADHcopeptinargipressinvasopressin-neurophysin II-copeptinprepro-arginine-vasopressin-neurophysin IIAVP-NPIIAVPvasopressinarginine-vasopressinantidiuretic hormoneneurohypophysealprepro-AVP-NP IIExternal IDs GeneCards: [1] Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) n/a n/a PubMed searchn/a n/a Wikidata
වේසොප්රෙසින් , හෙවත් ප්රතිමෞත්රල්ය හෝර්මෝනය (ADH ), ආර්ජිනීන් වේසොප්රෙසින් (AVP ) හෝ ආර්ජිප්රෙසින් ,[1] යනුවෙන් හැඳින්වෙන්නේ හෝර්මෝන synthesized as a peptide prohormone in neurons in the hypothalamus , and is converted to AVP. It then travels down the axon of that cell, which terminates in the posterior pituitary , and is released from vesicles into the circulation in response to extracellular fluid hypertonicity (hyperosmolality ). AVP has two primary functions. First, it increases the amount of solute-free water reabsorbed back into the circulation from the filtrate in the kidney tubules of the nephrons . Second, AVP constricts arterioles , which increases peripheral vascular resistance and raises arterial blood pressure .[2] [3] [4]
A third function is possible. Some AVP may be released directly into the brain from the hypothalamus, and may play an important role in social behavior , sexual motivation and pair bonding , and maternal responses to stress.[5]
Vasopressin induces differentiation of stem cells into cardiomyocytes and promotes heart muscle homeostasis.[6]
It has a very short half-life, between 16–24 minutes.[4]
↑ Anderson DA (2012). Dorland's Illustrated Medical Dictionary (32nd ed.). Elsevier. ISBN 978-1-4160-6257-8 .
↑ Marieb, Elaine (2014). Anatomy & physiology . Glenview, IL: Pearson Education, Inc. ISBN 978-0-321-86158-0 .
↑ Caldwell HK, Young WS III (2006). "Oxytocin and Vasopressin: Genetics and Behavioral Implications". In Lajtha A, Lim R (eds.). Handbook of Neurochemistry and Molecular Neurobiology: Neuroactive Proteins and Peptides (3rd ed.). Berlin: Springer. pp. 573–607. ISBN 978-0-387-30348-2 .
↑ 4.0 4.1 Babar SM (October 2013). "SIADH associated with ciprofloxacin". The Annals of Pharmacotherapy . 47 (10): 1359–63. doi :10.1177/1060028013502457 . PMID 24259701 .
↑ Insel TR (March 2010). "The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior" . Neuron (English බසින්). 65 (6): 768–79. doi :10.1016/j.neuron.2010.03.005 . PMC 2847497 . PMID 20346754 . {{cite journal }}
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↑ Costa A, Rossi E, Scicchitano BM, Coletti D, Moresi V, Adamo S (September 2014). "Neurohypophyseal Hormones: Novel Actors of Striated Muscle Development and Homeostasis" . review. European Journal of Translational Myology . 24 (3): 3790. doi :10.4081/bam.2014.3.217 . PMC 4756744 . PMID 26913138 .
වැඩිදුර කියවීමට [ සංස්කරණය ]
සැකිල්ල:PDB Gallery
සැකිල්ල:Hormones
සැකිල්ල:Renal physiology
සැකිල්ල:Neuropeptides
සැකිල්ල:Neurotransmitters
සැකිල්ල:Oxytocin and vasopressin receptor modulators