Chlorphenamine

විකිපීඩියා, නිදහස් විශ්වකෝෂය වෙතින්
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Chlorphenamine
Chlorphenamine.svg
Systematic (IUPAC) name
3-(4-Chlorophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine
Clinical data
Trade names Chlor-Trimeton; Piriton
AHFS/Drugs.com Monograph
MedlinePlus a682543
Pregnancy cat. A (AU) B (US)
Legal status Pharmacist Only (S3) (AU) P (UK) OTC (US)
Routes By mouth, IV, IM, SC
Pharmacokinetic data
Bioavailability 25 to 50%
Protein binding 72%
Metabolism Hepatic (CYP2D6)
Half-life 13.9–43.4 hours[1]
Excretion Renal
Identifiers
CAS number 113-92-8 X mark.svgN[??]
ATC code R06AB04
PubChem CID 2725
IUPHAR ligand 1210
DrugBank DB01114
ChemSpider 2624 YesY
UNII 3U6IO1965U YesY
KEGG D07398 YesY
ChEBI CHEBI:52010 YesY
ChEMBL CHEMBL505 YesY
Chemical data
Formula C16H19ClN2 
Physical data
Solubility in water 0.55 g/100 mL, liquid mg/mL (20 °C)
 X mark.svgN (what is this?)  (verify)

Chlorphenaminechlorpheniramine, CP, හෝ CPM) යනු පළමු පරම්පරාවේ ප්‍රතිහිස්ටමින් (first-generation antihistamine) ඖෂධයකි.

මූලාශ්‍ර[සංස්කරණය]

  1. Yasuda SU, Wellstein A, Likhari P, Barbey JT, Woosley RL (1995). "Chlorpheniramine plasma concentration and histamine H1-receptor occupancy". Clin. Pharmacol. Ther. 58 (2): 210–20. PMID 7648771. doi:10.1016/0009-9236(95)90199-X. 
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