වේසොප්‍රෙසින්

විකිපීඩියා වෙතින්
(වේසොප්‍රෙසීන් වෙතින් යළි-යොමු කරන ලදි)
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Vasopressin labeled.png
Arginine vasopressin3d.png
Systematic (IUPAC) name
1-{[(4R,7S,10S,13S,16S,19R)-19-Amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-p rolyl-L-arginylglycinamide
Clinical data
Legal status ?
Pharmacokinetic data
Protein binding 1%
Metabolism ප්‍රධාන වශයෙන් අක්මාව සහ වෘක්කවල
Half-life 10–20 මිනිත්තු
Excretion මූත්‍ර
Identifiers
CAS number 11000-17-2 YesY[??]
ATC code H01BA01
PubChem CID 644077
IUPHAR ligand 2168
DrugBank DB00067
ChemSpider 559126 YesY
UNII Y4907O6MFD YesY
KEGG D00101 YesY
ChEBI CHEBI:9937 YesY
ChEMBL CHEMBL373742 YesY
Synonyms Antidiuretic hormone (ADH); arginine vasopressin (AVP); argipressin
Chemical data
Formula C46H65N15O12S2 
Physical data
Density 1.6±0.1 g/cm³
Arginine vasopressin
Identifiers
Aliasesvasopressin-neurophysin 2-copeptinADHcopeptinargipressinvasopressin-neurophysin II-copeptinprepro-arginine-vasopressin-neurophysin IIAVP-NPIIAVPvasopressinarginine-vasopressinantidiuretic hormoneneurohypophysealprepro-AVP-NP II
External IDsGeneCards: [1]
RNA expression pattern
PBB GE AVP 207848 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

වේසොප්‍රෙසින්, හෙවත් ප්‍රතිමෞත්‍රල්‍ය හෝර්මෝනය (ADH), ආර්ජිනීන් වේසොප්‍රෙසින් (AVP) හෝ ආර්ජිප්‍රෙසින්,[1] යනුවෙන් හැඳින්වෙන්නේ හෝර්මෝන synthesized as a peptide prohormone in neurons in the hypothalamus, and is converted to AVP. It then travels down the axon of that cell, which terminates in the posterior pituitary, and is released from vesicles into the circulation in response to extracellular fluid hypertonicity (hyperosmolality). AVP has two primary functions. First, it increases the amount of solute-free water reabsorbed back into the circulation from the filtrate in the kidney tubules of the nephrons. Second, AVP constricts arterioles, which increases peripheral vascular resistance and raises arterial blood pressure.[2][3][4]

A third function is possible. Some AVP may be released directly into the brain from the hypothalamus, and may play an important role in social behavior, sexual motivation and pair bonding, and maternal responses to stress.[5]

Vasopressin induces differentiation of stem cells into cardiomyocytes and promotes heart muscle homeostasis.[6]

It has a very short half-life, between 16–24 minutes.[4]

ආශ්‍රේයයන්[සංස්කරණය]

  1. Dorland's Illustrated Medical Dictionary (32nd සංස්.). Elsevier. 2012. ISBN 978-1-4160-6257-8. https://books.google.com/?id=mNACisYwbZoC&printsec=frontcover&dq=Dorland%27s+Illustrated+Medical+Dictionary#v=snippet&q=argipressin&f=false. 
  2. Marieb, Elaine (2014). Anatomy & physiology. Glenview, IL: Pearson Education, Inc. ISBN 978-0-321-86158-0. 
  3. "Oxytocin and Vasopressin: Genetics and Behavioral Implications". Handbook of Neurochemistry and Molecular Neurobiology: Neuroactive Proteins and Peptides (3rd සංස්.). Berlin: Springer. 2006. පිටු 573–607. ISBN 978-0-387-30348-2. http://refworks.springer.com/mrw/fileadmin/pdf/Neurochemistry/0387303480C25.PDF. 
  4. 4.0 4.1 Babar SM (October 2013). "SIADH associated with ciprofloxacin". The Annals of Pharmacotherapy. 47 (10): 1359–63. doi:10.1177/1060028013502457. PMID 24259701.
  5. Insel TR (March 2010). "The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior". Neuron (in English). 65 (6): 768–79. doi:10.1016/j.neuron.2010.03.005. PMC 2847497. PMID 20346754.CS1 maint: unrecognized language (link)
  6. Costa A, Rossi E, Scicchitano BM, Coletti D, Moresi V, Adamo S (September 2014). "Neurohypophyseal Hormones: Novel Actors of Striated Muscle Development and Homeostasis". review. European Journal of Translational Myology. 24 (3): 3790. doi:10.4081/bam.2014.3.217. PMC 4756744. PMID 26913138.

වැඩිදුර කියවීමට[සංස්කරණය]


සැකිල්ල:PDB Gallery සැකිල්ල:Hormones සැකිල්ල:Renal physiology සැකිල්ල:Neuropeptides සැකිල්ල:Neurotransmitters සැකිල්ල:Oxytocin and vasopressin receptor modulators

"https://si.wikipedia.org/w/index.php?title=වේසොප්‍රෙසින්&oldid=457609" වෙතින් සම්ප්‍රවේශනය කෙරිණි